Dopamine release via the vacuolar ATPase V0 sector c-subunit, confirmed in N18 neuroblastoma cells, results in behavioral recovery in hemiparkinsonian mice
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Dopamine release via the vacuolar ATPase V0 sector c-subunit, confirmed in N18 neuroblastoma cells, results in behavioral recovery in hemiparkinsonian mice.
A 16-kDa proteolipid, mediatophore, in Torpedo electric organs mediates Ca(2+)-dependent acetylcholine release. Mediatophore is identical to the pore-forming stalk c-subunit of the V0 sector of vacuolar proton ATPase (ATP6V0C). The function of ATP6V0C in the mammalian central nervous system is not clear. Here, we report transfection of adeno-associated viral vectors harboring rat ATP6V0C into t...
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Neurotransmitter release through the V0 sector of V-ATPase.
Neurotransmitter release occurs at specialized areas of the nerve terminal membrane, the active zones, where clusters of synaptic vesicles, the neurotransmitter-storing organelles, are observed (Couteaux and PeÂcot-Dechavassine 1974; Harlow et al. 2001). In resting conditions, a population of synaptic vesicles is docked to the active zone membrane, close to voltage-gated calcium channels (Robit...
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ژورنال
عنوان ژورنال: Neurochemistry International
سال: 2012
ISSN: 0197-0186
DOI: 10.1016/j.neuint.2011.12.021